To clarify the effect of nitric oxide synthase (nos) type iii 4b/a polymorphism on the susceptibility to diabetic nephropathy (dn) by meta-analysis, we performed a computerized search of pubmed, embase, chinese biomedical literature database, china science and technology journal database, chinese journal full-text database and wanfang to. Meta-analysis of the role of il-6 rs1800795 polymorphism in the susceptibility to prostate cancer: evidence based on 17 studies medicine (baltimore) 2017 96: 6126 association of il-6 -634c/g polymorphism and the risk of osteosarcoma in a chinese population biomed res 2017 volume 28 issue 22 9763. Background: interleukin-10-1082ag variant is the most widely investigated polymorphism in the il-10 gene in cancer susceptibilitya number of case control analysis showed the link between il-10-1082a g polymorphism and cancer risk in humans population methods: twenty three case–control eligible studies, comprising 4753 cases and 6086 controls were selected for the meta-analysis of il-10. This meta-analysis suggests that il-10-1082g/a, il-819c/t, and il-592c/a polymorphisms might be associated with tb susceptibility in certain ethnicities view full-text article. The meta-analysis involving 2723 subjects did not detect any association between the tnf -238g/a polymorphism and tuberculosis susceptibility tumor necrosis factor alpha (tnf-α) plays a key role in the containment of tuberculosis.
We undertook a meta-analysis using data from eight studies (5,122 cases/5,735 controls) where we investigated association of three brip1 polymorphisms with breast cancer risk table 2 shows the pro919ser findings where null effects (or 098–102) were detected in the overall analysis. The effect of novel polymorphisms in the interleukin-6 (il-6) gene on il-6 transcription and plasma il-6 levels, and an association with systemic-onset juvenile chronic arthritis j clin invest 1998 oct 1102(7):1369-76. Research article open access association of tnf-alpha, il-6 and il-1beta gene polymorphisms with polycystic ovary syndrome: a meta-analysis renyong guo1†, ying zheng2†, jiezuan yang3 and nengneng zheng2 abstract. Background: the gene polymorphism of interleukin-6 (il-6) has been shown to be implicated in tuberculosis susceptibility in many studies, but with conflicting results this study aimed to provide more accurate estimation of the relationship between il-6 gene polymorphism and tuberculosis risk.
C indian academy of sciences research article association of il-6 and mmp-3 gene polymorphisms with susceptibility to adolescent idiopathic scoliosis: a meta-analysis. Apolipoprotein e (apoe) gene has been reported to be associated with migraine and tension-type headache (tth), but the results are conflicting this study aimed to evaluate the association of apoe with migraine by a meta-analysis medline, isi web of knowledge, the cochrane central register of. The search yielded 67 articles, 7 studies [18, 22 – 27] contain 1230 dn patients and 1334 diabetic controls were finally recruited into our meta-analysis according to the inclusion and exclusion criteria, all studies reporting the association among apai, bsmi, foki, taqi of vdr gene polymorphisms and dn susceptibility (fig 1. Published data on the associations between tumor necrosis factor-alpha (tnf-) promoter -308ga and -238ga polymorphisms and cervical cancer risk are inconclusiveto derive a more precise estimation of the relationship, a meta-analysis was performed.
However, the current meta-analysis was the most comprehensive assessment of the association between il-10 -1082 a/g polymorphism and gastric cancer, which extended the previous meta-analyses with a larger sample size and different subgroups. In our meta-analysis, obvious heterogeneity was observed for il-10-1082g/a polymorphism in all genetic models, -819c/t polymorphism in heterozygous model and dominant model, and -592a/c polymorphism in all genetic models except for heterozygous model, whereas there was no obvious heterogeneity for il-6-174g/c polymorphism then, we used the. With this study we investigated the contribution of il-6 (-572g/c rs1800796) and il-6r (1:g154448302 t c rs7529229) polymorphisms on pathogenesis, and severity of aa in pediatric patients with aa: these results will guide further genetic researches to be performed on the role of il-6 and il-6r in aa.
This meta-analysis studied the association between interleukin 2 receptor a (il2ra) gene polymorphisms rs2104286 and rs12722489 and susceptibility to multiple sclerosis (ms) case-control genetic association studies published before january 2011 were retrieved from the pubmed and embase databases and the cochrane library. Overall meta-analysis and further subgroup analysis the combined results relating to the xrcc3 t241m polymorphism and hcc risk are summarized in figure 2 and table 2. Gpx-1 polymorphism meta-analysis cancer oxidative stress j chen, q cao and c qin contributed equally to this work this is a preview of subscription content, log in to check access. Interleukin-6 (il-6), a central proinflammatory cytokine, maintains immune homeostasis and also plays important roles in cervical cancer therefore, we aimed to evaluate any associations of il-6 gene polymorphisms at positions -174 and -572 with predisposition to cervical cancer in a chinese population. Therefore, this meta-analysis was performed to reveal the possible effect of the ifn-γ +874(t/a) polymorphism on susceptibility to aa to the best of the author’s knowledge, this meta-analysis is the first quantitative assessment of the association between ifn-γ +874t/a polymorphism and risk of aplastic anemia.
Research open access meta-analysis of the associations between tnf-α or il-6 gene polymorphisms and susceptibility to lung cancer wei zhou, shuxiang zhang, yingchun hu, jianrong na, na wang, xuan ma, lizhi yuan and fanzhen meng abstract. View this abstract online meta-analysis of the role of il-6 rs1800795 polymorphism in the susceptibility to prostate cancer: evidence based on 17 studies. In summary, our meta-analysis suggests that the il-10–1082a g and -819t c polymorphisms are associated with cervical cancer susceptibility, but with contradictory effects in contrast, no significant association was found between the il-10–592c a polymorphism and cervical cancer susceptibility. This meta-analysis was performed to provide a systematical assessment on the association of il-1α (+889 c/t) and il-1β (+3594 t/c) polymorphisms with low back pain pubmed, embase, chinese biomedical.
A meta-analysis in 2010 indicated that il-10-1082 polymorphism was not related to hbv infection in asia in another study conducted by zhang et al no significant differences were discovered in il-10 gene promoter polymorphisms among chronic hbv patients and controls. Sensitivity analysis was performed to assess the strength of each individual study in pooled results (sensitivity analysis of il-6-174 and il-10-1082 under different models is presented in supplementary fig s1 and s2. Polymorphisms and susceptibility of tuberculosis: evidence based on a meta-analysis the meta-analysis results suggest that il-6 -174g/c and -572c/g polymorphisms might be associated with the risk of tb no significant association was observed between the il-6 g/a nt565 polymorphism and tb risk associations between il-6 gene.
The results indicated no significant lung cancer susceptibility with tnf-α-308g/a or il-6-174g/c polymorphism in the overall study populations our findings are in accordance with most of the related studies summarized in this meta-analysis. Conclusions: this meta-analysis suggests that il-6 -634cg polymorphism is associated with susceptibility of dn, and il-6 -174gc polymorphism is not associated with dn susceptibility a larger sample size of studies or meta-analysis is necessary in the future research.